Name: Computational Approaches for Drug Solubility Measurements (en Inglés)
Price: 19860.00 CLP
Availability: InStock
Author: Singh, Dilpreet
ISBN: 9781685387228

portada Computational Approaches for Drug Solubility Measurements (en Inglés)

Formato

Libro Físico

Autor

Dilpreet Singh

Editorial

Notion Press

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

27.9 x 21.6 x 0.5 cm

Peso

0.25 kg.

ISBN13

9781685387228

Categorías

Métodos de investigación

Computational Approaches for Drug Solubility Measurements (en Inglés)

Dilpreet Singh (Autor) · Notion Press · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Computational Approaches for Drug Solubility Measurements (en Inglés)"

olubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. More than 40% NCEs (new chemical entities) developed in pharmaceutical industry are practically insoluble in water. Solubility is a major challenge for formulation scientist. Any drug to be absorbed must be present in the form of solution at the site of absorption. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.