Name: Discovering and Developing Molecules with Optimal Drug-Like Properties (en Inglés)
Price: 254240.00 CLP
Availability: InStock
Author: Templeton, Allen C. ; Byrn, Stephen R. ; Haskell, Roy J.
ISBN: 9781493948604

portada Discovering and Developing Molecules with Optimal Drug-Like Properties (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Templeton, Allen C. ; Byrn, Stephen R. ; Haskell, Roy J.

Idioma

Inglés

N° páginas

511

Encuadernación

Tapa Blanda

Dimensiones

23.4 x 15.6 x 2.7 cm

Peso

0.73 kg.

ISBN13

9781493948604

Categorías

Farmacia y prescripción
Química orgánica

Discovering and Developing Molecules with Optimal Drug-Like Properties (en Inglés)

Templeton, Allen C. ; Byrn, Stephen R. ; Haskell, Roy J. (Autor) · Springer · Tapa Blanda

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Reseña del libro "Discovering and Developing Molecules with Optimal Drug-Like Properties (en Inglés)"

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state propertiesand critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.