Name: Mathematical Modelling of Chromosome Replication and Replicative Stress (en Inglés)
Price: 181240.00 CLP
Availability: InStock
Author: Karschau, Jens
ISBN: 9783319362823

portada Mathematical Modelling of Chromosome Replication and Replicative Stress (en Inglés)

Formato

Libro Físico

Autor

Jens Karschau

Editorial

Springer

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

23.4 x 15.6 x 0.5 cm

Peso

0.15 kg.

ISBN13

9783319362823

Categorías

Física matemática
Biofísica
Bioquímica

Mathematical Modelling of Chromosome Replication and Replicative Stress (en Inglés)

Jens Karschau (Autor) · Springer · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Mathematical Modelling of Chromosome Replication and Replicative Stress (en Inglés)"

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.