Name: Mitochondrial Dynamics and Uncoupling Protein 2 In The Hippocampus (en Inglés)
Price: 72700.00 CLP
Availability: InStock
Author: Knut Husø Hasan Md. Mahdi / Lauritzen
ISBN: 9783659387852

portada Mitochondrial Dynamics and Uncoupling Protein 2 In The Hippocampus (en Inglés)

Formato

Libro Físico

Editorial

LAP LAMBERT Academic Publishing

Autor

Knut Husø Hasan Md. Mahdi / Lauritzen

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

ISBN13

9783659387852

Categorías

Biología

Mitochondrial Dynamics and Uncoupling Protein 2 In The Hippocampus (en Inglés)

Knut Husø Hasan Md. Mahdi / Lauritzen (Autor) · LAP LAMBERT Academic Publishing · Tapa Blanda

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Reseña del libro "Mitochondrial Dynamics and Uncoupling Protein 2 In The Hippocampus (en Inglés)"

Mitochondria are a crucial site of energy metabolism in neurons. The energy demand is higher in neurons than in most other cells, which is reflected by high consumption of oxygen in the brain. In neurodegenerative pathology, reactive oxygen species (ROS) may lead to oxidative stress and mitochondrial DNA (mtDNA) damage. The transgenic mutated uracil-DNA glycosylase 1 (mutUNG1) mice express the mutUNG1 enzyme, which induces mitochondrial toxicity, caused by high numbers of apurinic/apyrimidinic-sites in mtDNA of hippocampal neurons. The uncoupling protein 2 (Ucp2) has the ability to protect neurons against a critically high mitochondrial membrane potential, thereby reducing ROS production. This book has been articulated with recent findings of mitochondrial dynamics and localization of increased level of Ucp2 in different compartments of hippocampal pyramidal neurons in a mouse model of mitochondrial DNA toxicity. The significantly increased density of Ucp2 has been investigated in the somas of pyramidal neurons which could result from the large numbers of damaged mitochondria transported to the somas from different compartments of the neurons in the mutUNG1-expressing mice.