Name: Structure and Function of Intrinsically Disordered Proteins (en Inglés)
Price: 238710.00 CLP
Availability: InStock
Author: Tompa, Peter ; Fersht, Alan
ISBN: 9781420078923

portada Structure and Function of Intrinsically Disordered Proteins (en Inglés)

Formato

Libro Físico

Autor

Peter Tompa

Alan Fersht

Editorial

CRC Press

Idioma

Inglés

N° páginas

360

Encuadernación

Tapa Dura

Dimensiones

23.6 x 16.3 x 2.3 cm

Peso

0.64 kg.

ISBN

9781420078923

ISBN13

9781420078923

Categorías

Fisiologiía
Farmacología

Structure and Function of Intrinsically Disordered Proteins (en Inglés)

Peter Tompa (Autor) · Alan Fersht (Autor) · CRC Press · Tapa Dura

Libro Físico

$ 238.710

$ 397.850

Ahorras: $ 159.140

40% descuento

Envío normal

Origen: Reino Unido (Costos de importación incluídos en el precio)

Se enviará desde nuestra bodega entre el Martes 23 de Julio y el Viernes 02 de Agosto.

Lo recibirás en cualquier lugar de Chile entre 1 y 3 días hábiles luego del envío.

Reseña del libro "Structure and Function of Intrinsically Disordered Proteins (en Inglés)"

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field.After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the book focuses on physical techniques for the identification and characterization of IDPs. It discusses proteomic and bioinformatic approaches and shows how IDPs behave under crowding conditions in living cells. The next several chapters describe the structure, correlating biological processes, and molecular mechanisms of IDPs. The author also explores the evolutionary advancement of structural disorder in proteomes and possible ways of extending the structure-function paradigm to encompass both ordered and disordered states of proteins. He concludes with discussions on the involvement of IDPs in various diseases and how to establish rational drug design through detailed characterization of IDPs.Although drug discovery rates have leveled off, new insight generated by the study of IDPs may offer fresh strategies for drug development. This work illustrates how these proteins defy the structure-function paradigm and play important regulatory and signaling roles.